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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHANK1 All Species: 4.55
Human Site: S482 Identified Species: 11.11
UniProt: Q9Y566 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y566 NP_057232.2 2161 224959 S482 S A P T T K L S S G T L R S A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001099818 1269 136588
Dog Lupus familis XP_541475 1171 125680
Cat Felis silvestris
Mouse Mus musculus Q4ACU6 1805 192199 L295 D S R G L T P L Y H S A L G G
Rat Rattus norvegicus Q9WV48 2167 226317 S482 S A P S T K L S S G T L R S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507367 1367 148107
Chicken Gallus gallus XP_426415 1770 194380 A260 A D M C A Q N A S G N T A L H
Frog Xenopus laevis Q52KW0 1292 141161
Zebra Danio Brachydanio rerio NP_001121819 1800 196374 H290 C H D E N G W H E I H Q A C R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610925 1871 198983 P359 I V P F R G P P R Y N P K R R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 23.2 52 N.A. 39.1 93.3 N.A. 26.7 39.1 22.5 37.8 N.A. 22.6 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 33.4 53.2 N.A. 49.8 95.1 N.A. 35.4 50.8 34 50.5 N.A. 35.1 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 0 0 N.A. 0 93.3 N.A. 0 13.3 0 0 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 0 0 N.A. 13.3 100 N.A. 0 33.3 0 0 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 20 0 0 10 0 0 10 0 0 0 10 20 0 20 % A
% Cys: 10 0 0 10 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 10 10 10 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 10 0 20 0 0 0 30 0 0 0 10 10 % G
% His: 0 10 0 0 0 0 0 10 0 10 10 0 0 0 10 % H
% Ile: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 20 0 0 0 0 0 0 10 0 0 % K
% Leu: 0 0 0 0 10 0 20 10 0 0 0 20 10 10 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 10 0 0 0 20 0 0 0 0 % N
% Pro: 0 0 30 0 0 0 20 10 0 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 0 10 0 0 0 % Q
% Arg: 0 0 10 0 10 0 0 0 10 0 0 0 20 10 20 % R
% Ser: 20 10 0 10 0 0 0 20 30 0 10 0 0 20 0 % S
% Thr: 0 0 0 10 20 10 0 0 0 0 20 10 0 0 0 % T
% Val: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _